Buckle up and strap yourself in because the first great trailer of the year is here, and comes with it the promise of an equally great movie.

Warner Bros.’ New Line Cinema has released the splatter-fueled first trailer for They Will Kill You, a genre mash-up that blends quippy, blood-soaked carnage à la Kill Bill with the cult paranoia of You’re Next, the bone-crunching action of The Raid, and the high-stakes, game-on savagery of Ready or Not.

“The film unleashes a blood-soaked, high-octane horror-action-comedy in which a young woman (Zazie...